Fused pyridone m1 receptor positive allosteric modulators

Details Fused pyridone m1 receptor positive allosteric modulators Fused pyridone m1 receptor positive allosteric modulators

C - Chemistry, Metallurgy

07

D

C07D 215/56 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2714415

The present invention is directed to fused pyridone compounds of formula (I) (I) that are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

La présente invention porte sur les composés de pyridone fusionnée représentés par la formule (I) (I), qui sont des modulateurs allostériques positifs du récepteur M1 et qui se révèlent utiles dans le traitement de maladies impliquant le récepteur M1 comme, par exemple, la maladie dAlzheimer, la schizophrénie, la douleur ou les troubles du sommeil. Linvention concerne également des compositions pharmaceutiques renfermant lesdits composés, ainsi que lutilisation desdits composés et compositions dans le traitement de maladies à médiation par le récepteur M1.

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