Plasmids with a translation start-stop-start codon...

Details Plasmids with a translation start-stop-start codon... Plasmids with a translation start-stop-start codon...

C - Chemistry, Metallurgy

12

N

167/135, 167/37,

C12N 15/70 (2006.01) A61K 39/108 (2006.01) C07K 14/245 (2006.01) C12P 21/02 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2006534

- 1 - BEHRINGWERKE AKTIENGESELLSCHAFT 88/B 047 - Ma 740 Abstract of the Disclosure Dr. Lp/rd Plasmids with a translation start-stop-start codon con- figuration for the expression of proteins in E. coli The invention relates to expression plasmids which bring about a considerable increase in the expression of proteins, in particular of the thermolabile E. coli enterotoxin subunit B (LT-B). This entails a strong promoter being placed upstream of the DNA coding for LT-B in such a way that the so-called Shine-Dalgarno sequence GGGA of the LT-B gene is located six base-pairs (bp) in front of the LT-B translation start, with reten- tion of the stop codon TGA of the LT-A sequence which precedes in the natural case.

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