A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2651178
The present invention provides methods, compositions and vaccines for specifically targeting immunoglobulin associated cell-surface determinants that are not shed into the blood of a host. In some cases, the immunoglobulin associated cell-surface determinants will be involved in various B-cell disorders. The methods involve administering an IACSD targeting element to a B-cell. The method can employ treating an individual with a B-cell associated disorder by administering an effective amount of an IACSD targeting preparation. The compositions include isolated antibodies where the antibodies associate with an immunoglobulin associated cell-surface determinants. The invention also includes vaccines that immunize against immunoglobulin associated cell-surface determinants.
La présente invention concerne des procédés, des compositions et des vaccins destinés au ciblage spécifique de déterminants de surface cellulaire associés à l'immunoglobuline qui ne sont pas diffusés dans le sang d'un hôte. Dans certains cas, les déterminants de surface cellulaire associés à l'immunoglobuline seront impliqués dans divers troubles liés aux lymphocytes B. Les procédés consistent à administrer un élément de ciblage IACSD à un lymphocyte B. Le procédé peut consister à traiter un individu souffrant d'un trouble associé aux lymphocytes B en lui administrant une quantité efficace de préparation de ciblage IACSD. Les compositions incluent des anticorps isolés, lesdits anticorps s'associant à des déterminants de surface cellulaire associés à l'immunoglobuline. L'invention inclut également des vaccins qui conduisent à une immunisation contre lesdits déterminants de surface cellulaire associés à l'immunoglobuline.
Kostyal David A.
Welt Sydney
Guthrie Foundation For Education & Research
Mbm Intellectual Property Law Llp
LandOfFree
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