C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01) A61K 31/665 (2006.01) C07D 307/60 (2006.01) C07D 307/94 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 473/00 (2006.01) C07D 473/38 (2006.01) C07D 491/10 (2006.01) C07D 491/107 (2006.01) C07F 9/655 (2006.01)
Patent
CA 2168757
The invention comprises novel substituted tetronic acid type compound, 2,4-3(3H,5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the treatment of a person with AIDS or AIDS related diseases. The compounds may be used in the attempt to retard the further replication of any retrovirus containing the aspartyl protease enzyme. Compounds are represented by formula (1), wherein 3 tautomers of the same structure are shown, R1, R2 and R3 are replaced with various substituents.
L'invention concerne de nouveaux composés de type acide tétronique substitué, les 2,4-(3H,5H)-furandiones, qui servent à inhiber une enzyme, la protéase du VIH. Ces composés peuvent se révéler utiles pour le traitement d'une personne souffrant du SIDA ou de para-SIDA. Ces composés peuvent s'utiliser pour tenter de retarder la réplication ultérieure de tout rétrovirus contenant l'enzyme aspartyle protéase. Ces composés sont représentés par la formule (1), dans laquelle figurent 3 tautomères de même structure, R1, R2 et R3 étant remplacés par différents substituants.
Aristoff Paul A.
Bundy Gordon L.
Chrusciel Robert A.
Howe W. Jeffrey
Maggiora Linda L.
Macrae & Co.
Pharmacia & Upjohn Company
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