Naphthyl compounds, intermediates, compositions, and methods...

Details Naphthyl compounds, intermediates, compositions, and methods... Naphthyl compounds, intermediates, compositions, and methods...

C - Chemistry, Metallurgy

07

D

C07D 211/20 (2006.01) A61K 31/075 (2006.01) A61K 31/135 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07C 41/28 (2006.01) C07C 43/20 (2006.01) C07C 43/23 (2006.01) C07C 43/295 (2006.01) C07C 45/46 (2006.01) C07C 45/71 (2006.01) C07C 47/546 (2006.01) C07C 47/575 (2006.01) C07C 49/755 (2006.01) C07C 51/367 (2006.01) C07C 67/03 (2006.01) C07C 67/317 (2006.01) C07C 69/017 (2006.01) C07D 207/04 (2006.01) C07D 211/06 (2006.01) C07D 223/02 (2006.01) C07D 265/30 (2

Patent

CA 2264002

The invention are naphthyl compounds of formula (1), wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOAr where Ar is phenyl or sustituted phenyl, -O(CO)OAr where Ar is phenyl or substituted phenyl, -OCO(C1--C6 alkyl), -O(CO)O(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); R2 is -H, -F, -Cl, -OH, -O(C1-C4 alkyl), -OCOAr where Ar is phenyl or substituted phenyl, -O(CO)OAr where Ar is phenyl or substituted phenyl, -OCO(C1--C6 alkyl), -O(CO)O(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); R3 and R4 are, independently, -H, -F, -Cl, CH3, -OH, -O(C1-C4 alkyl), OCOAr where Ar is phenyl or substituted phenyl, -OCO(C1-C6 alkyl), -O(CO)O(C1-C6 alkyl), or -OSO2(C4-C6 alkyl), with the proviso that both R3 and R4 cannot be hydrogen; n is 2 or 3; and R5 is 1-piperidinyl, 1-pyrrolidinyl, methyl--1 -pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof, their intermediates, compositions and method of use.

L'invention a pour objet des composés de naphtyle, représentés par la formule (I), dans laquelle R<1> est -H, -OH, -O(C1-C4 alkyle), -OCOAr, Ar étant un phényle ou un phényle substitué; -O(CO)OAr, Ar étant un phényle ou un phényle substitué; -OCO(C1-C6 alkyle), -O(CO)O(C1-C6 alkyle), ou -OSO2(C4-C6 alkyle), R<2> est -H, -F, -Cl, -OH, -O(C1-C4 alkyle), -OCOAr, Ar étant un phényle ou un phényle substitué, -O(CO)OAr, Ar étant un phényle ou un phényle substitué; -OCO(C1-C6 alkyle), -O(CO)O(C1-C6 alkyle), ou -OSO2(C4-C6 alkyle); R<3> et R<4> sont, chacun séparément, -H, -F, -Cl, -CH3, -OH, -O(C1-C4 alkyle), -OCOAr, Ar étant un phényle ou un phényle substitué, -OCO(C1-C6 alkyle), -O(CO)O(C1-C6 alkyle), ou -OSO2(C4-C6 alkyle) R<3> et R<4> ne pouvant être hydrogène; n est 2 ou 3; et R<5> est 1-pipéridinyle, 1-pyrrolidinyle, méthyl-1-pyrrolidinyle, diméthyl-1-pyrrolidinyle, 4-morpholino, diméthylamino, diéthylamino, ou 1-héxaméthylèneimino. L'invention a également pour objet un sel ou un solvant pharmaceutiquement acceptable desdits composés, leurs intermédiaires, des compositions desdits composés et un procédé d'utilisation.

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