Substituted imidazolidines, method for the production...

Details Substituted imidazolidines, method for the production... Substituted imidazolidines, method for the production...

C - Chemistry, Metallurgy

07

D

C07D 233/50 (2006.01) A61K 31/4168 (2006.01) A61K 31/4184 (2006.01) A61P 11/00 (2006.01) A61P 25/00 (2006.01) A61P 33/14 (2006.01) A61P 43/00 (2006.01) C07D 235/02 (2006.01) C07D 235/30 (2006.01)

Patent

CA 2470856

The invention relates to new imidazolidine-type compounds of formula (I) in which R1 to R7 have the meanings disclosed in the claims. Said compounds represent potent inhibitors of sodium/hydrogen exchanger (NHE), particularly NHE. These novel compounds are used to produce a drug for the therapy or prophylaxis of the central nervous system, lipometabolism, infestations by ectoparasites, dysfunctions of the gall and for improving respiratory drive. The inventive compounds are therefore used for the therapy of respiratory conditions in the following clinical states and diseases: malfunctioning central respiratory drive (e.g. sleep apnoea, sudden infant death, postoperative hypoxia), muscle-related breathing disturbances, breathing disturbances following long-term respiration, breathing disturbances when adapting to high mountain areas, obstructive sleep apnoea and a mixed type of sleep apnoea, acute and chronic lung diseases with hypoxia and hypercapnia. Said compounds also increase the muscle tone in the upper respiratory tract so as to suppress snoring.

L'invention concerne de nouveaux composés du type des imidazolidines de formule (I), dans laquelle R1 à R7 ont les significations indiquées dans les revendications. Ces composés constituent des inhibiteurs puissants de l'échangeur Na+/H+ (NHE), en particulier du NHE3. Lesdits composés servent à produire un médicament destiné à traiter ou prévenir des troubles du système nerveux central, du lipométabolisme ou de la fonction biliaire et des infections ectoparasitaires et à améliorer la commande respiratoire. Ils sont utilisés pour traiter des problèmes respiratoires liés aux maladies et états cliniques suivants : trouble de la commande respiratoire centrale (p. ex. apnée centrale du sommeil, mort subite du nourrisson, hypoxie postopératoire), troubles respiratoires d'origine musculaire, troubles respiratoires à la suite d'une respiration artificielle de longue durée, troubles respiratoires lors de l'adaptation à des zones de haute montagne, forme obstructive et forme mixte d'apnée du sommeil, maladies pulmonaires aiguës et chroniques avec hypoxie et hypercapnie. Ces composés augmentent par ailleurs le tonus musculaire des voies respiratoires supérieures, ce qui permet de traiter le ronflement.

Affiliated with

Also associated with

Rating

Substituted imidazolidines, method for the production... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted imidazolidines, method for the production..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted imidazolidines, method for the production... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1506554