Process for producing...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/48 (2006.01) A61K 31/16 (2006.01) A61P 25/24 (2006.01) C07D 307/93 (2006.01)

Patent

CA 2594721

A process for producing (Z)-1-phenyl-1-(N,N-diethyl~aminocarbonyl)-2- phthalimidomethylcyclopropane which comprises reacting (Z)-1-phenyl-1-(N,N- diethylamino~carbonyl)-2-hydroxymethylcyclopropane with an orthoester and a BrDnsted acid and then reacting the reaction product with a phthalimidizing agent. Also provided is a process for producing (Z)-1-phenyl-1-(N,N- diethylaminocarbonyl)-2-aminomethyl~cyclopropane hydrochloride via that process.

L~invention concerne un procédé de production du (Z)-1-phényl-1-(N,N-diéthylaminocarbonyl)-2-phtalimidométhylcyclopropane qui consiste à faire réagir le (Z)-1-phényl-1-(N,N-diéthylaminocarbonyl)-2-hydroxyméthylcyclopropane avec un orthoester et un acide de Brönsted et puis à faire réagir le produit de la réaction avec un agent de phtalimidation. L~invention concerne en outre un procédé de production du chlorhydrate de (Z)-1-phényl-1-(N,N-diéthylaminocarbonyl)-2-aminométhylcyclopropane par l'intermédiaire du procédé précédent.

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