Coagulation factor iii polymorphisms associated with...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A61K 45/00 (2006.01) A61P 7/02 (2006.01) A61P 29/00 (2006.01) C07H 21/00 (2006.01) C12N 15/57 (2006.01) C40B 40/06 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2612859

ABSTRACT The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition or hypertension. The method generally comprises determining a coagulation factor III genotype(s) of a subject for one or more SNPs, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the subject to recover from the inflammatory condition and identifying subjects based on their prognosis. The invention also provides for methods of identifying potential subjects having an inflammatory condition who are more likely to benefit from treatment with an anti-inflammatory agent or anti-coagulant agent and subsequent to treatment recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.

L'invention concerne des méthodes et des kits pour obtenir un pronostic relatif à un sujet souffrant d'un état inflammatoire ou d'hypertension ou présentant le risque de les développer. La méthode consiste à déterminer un ou des génotype(s) de facteur de coagulation III d'un sujet pour un ou plusieurs SNP, à comparer le génotype déterminé avec des génotypes connus pour le polymorphisme qui correspondent à l'aptitude du sujet à récupérer suite à un état inflammatoire, et à identifier des sujets sur la base de pronostics. La présente invention porte également sur des méthodes pour identifier des sujets candidats à un état inflammatoire et plus susceptibles de bénéficier d'un traitement par anti-inflammatoire ou anticoagulant et de récupérer d'un état inflammatoire après traitement. L'invention concerne aussi des méthodes pour traiter des sujets de ce type au moyen d'un anti-inflammatoire ou d'un anticoagulant en fonction du génotype du sujet.

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