Substituted...

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C - Chemistry, Metallurgy

07

D

C07D 271/10 (2006.01) A61K 31/4245 (2006.01) A61P 3/08 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2651710

Compounds of formula (I), or salts thereof, which inhibit acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein R1, R2 and R3 are each independently selected from hydrogen, fluoro, chloro, cyano, trifluoromethyl, trifluoromethoxy and difluoromethoxy; together with processes for their preparation, pharmaceutical compositions containing them and their use as medicaments.

L'invention concerne des composés de formule (I) ou des sels de ceux-ci, qui inhibent l'activité acétyl CoA (acétyl coenzyme A):diacylglycérol acyltransférase (DGAT1), dans laquelle R1, R2 et R3 sont chacun indépendamment choisis parmi hydrogène, fluoro, chloro, cyano, trifluorométhyle, trifluorométhoxy et difluorométhoxy conjointement à des procédés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en tant que médicaments.

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