Substituted benzoic acids

Details Substituted benzoic acids Substituted benzoic acids

C - Chemistry, Metallurgy

07

C

C07C 65/24 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) C07C 43/225 (2006.01) C07C 69/92 (2006.01) C07C 69/94 (2006.01) C07C 219/14 (2006.01) C07C 317/22 (2006.01)

Patent

CA 2110116

ABSTRACT The invention relates to compounds of the formula Image I wherein R is hydrogen, lower alkyl, -(CH2)2N(R3)2 or -CH2OOCR3 wherein R3 is lower alkyl; R1 is CH3(CH2)n-, wherein n is 9-17, or R4(CH2)p-, wherein p is 3-10 and R4 is 1- or 2-naphthyloxy, 2,3- or 3,4-dihydroxyphenyl, 2,3- or 3,4-dibenzyloxyphenyl, phenyl, phenoxy, or substituted phenyl or phenoxy wherein the substituent is selected from the group consisting of hydroxy, benzyloxy, methylsulfinyl, methylsulfonyl or phenyl; R2 is R4(CH2)p-, 1-adamantyl-CO- or diphenylmethyl- CO-, and, when R is hydrogen, a pharmaceutically acceptable salt with a base. The compounds of formula I are potent inhibitors of phospholipases A2 (PLA2's) and are therefore useful in the treatment of diseases, such as psoriasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia, and trauma induced inflammation, such as spinal cord injury.

Affiliated with

Also associated with

Rating

Substituted benzoic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted benzoic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted benzoic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1508177