Treatment of a trabecular meshwork whose cells are subject...

Details Treatment of a trabecular meshwork whose cells are subject... Treatment of a trabecular meshwork whose cells are subject...

A - Human Necessities

61

K

A61K 31/60 (2006.01) A61K 31/135 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/545 (2006.01)

Patent

CA 2222930

The invention concerns the recognition that certain non-steroidal anti- inflammatory agents can overcome or ameliorate limitations on trabecular meshwork cell division produced by environmental stresses (e.g., oxidative or phagocytic injury, or glucocorticoid exposure), and thus can be used to prevent or treatloss of trabecular cells found in certain forms of glaucoma and in normal aging. The use of such non-steroidal anti-inflammatory agents can ameliorate the severity, or prevent glaucoma.

Cette invention concerne la capacité de certains agents anti-inflammatoires non stéroïdiens de supprimer ou de réduire les limitations entravant la division cellulaire se produisant dans un tissu trabéculaire à cause de contraintes du milieu environnant (par exemple, blessures oxydantes ou phagocytaires, ou exposition à des glucocorticoïdes). Ces agents peuvent ainsi être utilisés afin de prévenir ou de traiter la perte de cellules trabéculaires que l'on rencontre dans certaines formes de glaucomes ou lors du processus normal de vieillissement. L'utilisation de tels agents anti-inflammatoires non stéroïdiens permet de limiter la gravité des glaucomes ou de les prévenir.

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