Use of a medicament and use of mixture of substances to...

Details Use of a medicament and use of mixture of substances to... Use of a medicament and use of mixture of substances to...

A - Human Necessities

61

K

A61K 31/12 (2006.01) A61K 45/06 (2006.01) A61P 31/00 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2240729

The invention relates to the use of a medicament with a mixture of substances and the use of a mixture of substances on the basis of active agents from the hypericum plant (St. John's wort) to produce a medicament. Extracts from St John's wort have long been used in medicine, but for a long time solely to treat psychogenic disorders and insomnia. Such extracts contain small quantities of polycyclic diones (hypericin, pseudohypericin and/or salts thereof). An anti-viral and especially anti-retroviral effect of hypericin and pseudohypercin in highly pure form has recently been observed. However, the administration of such preparations has considerable side-effects, making them useless for therapeutic use. According to the invention, the active agent hypericin is dispensed not in highly pure form, but mixed with known components of the plant extract. Here, the concentration of hypericin/pseudohypericin is between 0.05 and 50 %. This provides good anti- retroviral action while largely avoiding the undesired side-effects.

L'invention concerne l'utilisation d'un médicament avec un mélange de substances et l'utilisation d'un mélange de substances à base de principes actifs de la plante hypericum (millepertuis) pour la production d'un médicament. On utilise depuis longtemps des extraits du millepertuis en médecine, mais jusqu'ici exclusivement dans l'éventail des indications des troubles psychogènes et du sommeil. Lesdits extraits contiennent de faibles quantités de diones polycycliques (hypéricine, pseudohypéricine et/ou des sels de celles-ci). Récemment, on a observé l'efficacité antivirale et plus particulièrement antirétrovirale de l'hypéricine et de la pseudohypéricine sous une forme très pure. L'administration de ladite préparation provoque toutefois des effets secondaires importants, ce qui interdit une utilisation thérapeutique de celle-ci. Dans le procédé d'utilisation selon l'invention, le principe actif hypéricine/pseudohypéricine n'est pas administré sous sa forme très pure mais mélangé avec d'autres constituants connus comme constituants de l'extrait végétal. La concentration d'hypéricine/pseudohypéricine est comprise entre 0,05 % et 50 %. Ainsi, on obtient un bon effet antirétroviral et on supprime dans une large mesure les effets secondaires indésirables.

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