Treatment of cell-mediated immune diseases

Details Treatment of cell-mediated immune diseases Treatment of cell-mediated immune diseases

A - Human Necessities

61

K

A61K 31/203 (2006.01) A61K 31/232 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2301907

9-cis retinoic acid and pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, 9-cis retinal and pharmaceutically acceptable acetals thereof, and 9-cis retinol and pharmaceutically acceptable hydrolyzable esters thereof as well as metabolites of 9-cis retinoic acid have been found to be efficacious in treating T-helper cell type 1 mediated immune diseases in well tolerated doses. Preferably, the active ingredient is formulated as a medicament for oral or topical administration.

On a découvert que l'acide rétinoïque 9-cis et les sels pharmaceutiquement acceptables et les esters hydrolysables pharmaceutiquement acceptables de ce dernier, le rétinal 9-cis et les acétals pharmaceutiquement acceptables de ce dernier et le réthinol 9-cis et les esters hydrolysables pharmaceutiquement acceptables de ce dernier ainsi que les métabolites de l'acides rétinoïque 9-cis sont efficaces dans le traitement des maladies immunes propagées par les cellules T auxiliaires du type 1 suivant des doses bien tolérées. De préférence l'ingrédient actif est formulé sous forme d'un médicament destiné à l'administration orale ou topique.

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