Pharmacokinetically improved compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/517 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2602254

The present invention relates to inhibitors of ROCKl and R0CK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCKl and or R0CK2 that are useful for the treatment of disease.

La présente invention concerne des inhibiteurs de ROCK1 et de ROCK2, et des méthodes de modulation des propriétés pharmacocinétiques et/ou pharmacodynamiques desdits composés. L'invention concerne en outre des méthodes d'inhibition de ROCK1 et de ROCK2, qui sont utiles pour le traitement de maladies.

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