Phosphocholinate cardenolides

Details Phosphocholinate cardenolides Phosphocholinate cardenolides

A - Human Necessities

61

K

A61K 31/665 (2006.01) A61K 31/66 (2006.01) C07C 69/00 (2006.01) C07C 69/74 (2006.01) C07F 9/06 (2006.01) C07J 19/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2290947

Disclosed herein are cardenolides and related compounds covalently linked to phosphocholine moieties and pharmaceutical formulations comprising such compounds. Also disclosed herein are methods for treating hypertension, premenstrual syndrome (PMS), preeclampsia and polycystic kidney disease using the compounds.

L'invention concerne des cardénolides et des composés apparentés liés par covalence à des fractions de phosphocholine, ainsi que des formulations pharmaceutiques comprenant de tels composés. L'invention décrit également des procédés de traitement de l'hypertension, du syndrome prémenstruel, de la prééclampsie et du rein polykistique à l'aide des composés de l'invention.

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