C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/10 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 211/60 (2006.01)
Patent
CA 2599352
The present invention is concerned with certain novel derivatives of Formula (I): wherein X and R1 to R10 are as described in the specification, and where either R5 is OH, -NRdORa or NRd-NRbRc, or R7 is -NRdORa or NRd-NRbRc, or C=R7R8 is C=NORa or C=N-NRbRc, which may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase mediated disorders.
La présente invention a trait à de nouveaux dérivés de formule (I), dans laquelle: X et R1 à R10 sont tels que définis dans la description, et dans laquelle R5 est OH. -NrdORa ou -NRd-NRbRc, ou R7 est -NRdORa ou -NRd-NRbRc, ou C=R7R8 est C=NORa ou C=N-NRbRc, qui peuvent être utiles dans la fabrication de compositions pharmaceutiques pour le traitement de troubles médiés par des lipoxygénases. Ils peuvent également être utiles dans la fabrication de formulations pharmaceutiques pour le traitement de troubles médiés par des lipoxygénases.
Chen Jian
Zhang Wei
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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