C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/22 (2006.01) A61K 31/47 (2006.01) C07D 471/18 (2006.01) C07D 491/18 (2006.01) C07D 495/18 (2006.01)
Patent
CA 2206446
Novel polycylic aminopyridine compounds as inhibitors of acetylcholinesterase, process for their preparation and utilization thereof. The polycylic aminopyridine compounds have formula (I) wherein the various radicals have the meanings indicated in the description of the invention. The process for the preparation of said compounds is characterized in that ketones having general formula (II) are caused to react with aminonitriles having general formula (III), and, if necessary, the compounds of formula (I) are alkylated, aralkylated or acylated, or the corresponding ketonic precursor is reduced. The compounds having the general formula (I) are specially appropriate for the preparation of medicaments useful against memory troubles, such as senile dementia or the Alzheimer disease.
Nouveaux composés aminopyridiniques polycycliques inhibiteurs de l'acétylcholinestérase, leur procédé de préparation et leur utilisation. Les composés aminopyridiniques polycycliques ont la formule (I) dans laquelle les divers radicaux ont les significations indiquées dans le descriptif de l'invention. Le procédé de préparation de ces composés se caractérise en ce que l'on fait réagir des cétones ayant la formule générale (II) avec des aminonitriles ayant la formule générale (III), et, si nécessaire, les composés de la formule (I) sont alkylés, aralkylés ou acylés, ou bien on réduit le précurseur cétonique correspondant. Les composés de la formule générale (I) sont particulièrement appropriés à la préparation de médicaments agissant contre les troubles de la mémoire tels que la démence sénile ou la maladie d'Alzheimer.
Badia Sancho Albert
Banos Diez Josep Eladi
Camps Garcia Pelayo
Contreras Lascorz Joan
El Achab Rachid
Camps Garcia Pelayo
Medichem S.a.
Ridout & Maybee Llp
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