Compositions comprising 2-phenyl-indole compounds and...

Details Compositions comprising 2-phenyl-indole compounds and... Compositions comprising 2-phenyl-indole compounds and...

C - Chemistry, Metallurgy

07

D

C07D 209/12 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/454 (2006.01) C07D 209/10 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2331318

The present invention relates to the use of 3-[4-(2-phenyl-Indol-1-ylmethyl)- phenyl]Acrylamide compounds and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)benzyl]- 1H-indol-5-ol compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, the compounds having general formula (I) or (II).

L'invention concerne l'utilisation de composés 3-[4-(2-phényl-indol-1-ylméthyl)-phényl]acrylamide et de composés 2-phényl-1-[4-(amino-1-yl-alc-1-ynyl)benzyl]-1H-indol-5-ol, utiles en tant qu'agents oestrogènes; elle concerne également des compositions pharmaceutiques et des méthodes de traitement dans lesquelles on utilise ces composés, lesquels correspondent à la formule générale (I) ou (II).

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