Use of bacterial lipoprotein amino terminus in fusion...

Details Use of bacterial lipoprotein amino terminus in fusion... Use of bacterial lipoprotein amino terminus in fusion...

C - Chemistry, Metallurgy

12

N

530/15.12, 195/1

C12N 15/62 (2006.01) C07K 1/107 (2006.01) C07K 14/485 (2006.01) C07K 19/00 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2032914

ABSTRACT OF THE DISCLOSURE The present invention relates to a fusion plasmid for in vivo synthesis of a lipid modified polypeptide. The plasmid comprises a first DNA sequence encoding a lipoprotein signal peptide, preferably a bacterial lipoprotein signal peptide, and at least the first amino acid of a mature lipoprotein, preferably cysteine. In the DNA sequence, the preferred cysteine codon may be followed by codons for a few amino acids forming a .beta.-turn structure. These amino acids may also include a specific exogenous protease recognition cleavage site. A second DNA sequence encoding the desired polypeptide can be inserted into the fusion plasmid to produce the desired lipid modified polypeptide.

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