Crystalline forms of pitavastatin calcium

Details Crystalline forms of pitavastatin calcium Crystalline forms of pitavastatin calcium

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01) A61K 31/47 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2513837

The present invention is directed to new crystalline forms of Pitavastatin hernicalcium salt, referred to hereinafter as polymorphic Forms A, B, C, D, E and F, as well as the amorphous form. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and the amorphous form and pharmaceutical compositions comprising these crystalline forms or the amorphous form.

L'invention concerne des nouvelles formes cristallines de sel de hémicalcium de pitavastatine, ci-après désignées formes polymorphiques A, B, C, D, E et F; ainsi que sa forme amorphe. L'invention concerne en outre des procédés de préparation de ces formes cristallines et de la forme amorphe ainsi que des compositions pharmaceutiques comprenant lesdites formes cristallines ou ladite forme amorphe.

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