C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 501/24 (2006.01) C07D 498/04 (2006.01) C07F 9/6539 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2206199
The invention is concerned with a new process for the preparation of compounds of formula (see formula I) wherein R1 is trityl, acetyl or tetrahydropyranyl; R2 is hydrogen, hydroxy, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, lower alkynyl, aryl, aryloxy, aryl-lower alkyl, aryl-lower alkoxy or heterocyclyl or heterocyclyl-lower alkyl; lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aryl-lower alkyl, aryl, aryloxy, aryl-lower alkoxy, and heterocyclyl moieties being unsubstituted or substituted with at least one group selected from carboxy, amino, nitro, cyano, lower alkyl, lower alkoxy, hydroxy, halogen, -CONR21R22, -N(R22)COOR23, R22CO-, R22OCO- or R22COO-, wherein R21 is hydrogen, lower alkyl, or cycloalkyl; R22 is hydrogen or lower alkyl; R23 is lower alkyl, lower alkenyl or a carboxylic acid protecting group; Y is -S- and Z is -CH2- or Y is -CH2- and Z is -O-, by acylation of a compound of formula Image with an activated carboxylic acid derivative of formula Image wherein R3 is lower alkyl, and R1, R2, Y, Z have the significance given above; and it is further concerned with compounds of formula III.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
LandOfFree
Preparation of cephem- and isooxacephem derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation of cephem- and isooxacephem derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of cephem- and isooxacephem derivatives will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1511370