Retinoid receptor compositions and methods

Details Retinoid receptor compositions and methods Retinoid receptor compositions and methods

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/64 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12Q 1/34 (2006.01) C12Q 1/48 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2075182

The present invention re- lates to novel receptor polypep- tides, which, upon interaction with certain ligands, or activation by certain compounds, modulate transcription of certain genes by binding to cognate response ele- ments associated with promoters of such genes. The novel recep- tors of the invention modulate transcription in the presence of retinoid compounds. The recep- tors of the present invention dif- fer significantly from known reti- noid acid receptors, in protein primary sequence and in respon- siveness to exposure to various retinoids. The invention provides DNAs encoding the novel recep- tors, expression vectors for ex- pression of the receptors, cells transformed with such expres- sion vectors, cells co-transformed with such expression vectors and with reporter vectors to monitor modulation of transcription by the receptors, and methods of using such co- transformed cells in screening for compounds which are capable, directly or indirectly, of activating the receptors. The invention also provides nucleic acid probes for identifying DNAs which encode additional retinoid receptors of the same class as the novel receptors disclosed herein.

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