A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7036 (2006.01) A61J 3/02 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61L 24/06 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2567916
A method for producing antibiotic / antibiotics-particles characterized in that an aqueous solution of an amino glycoside-antibiotic or an aqueous solution comprising two or more amino glyco-side-antibiotics is mixed under agitation with a solvent mixture comprising isopropanol and at least one additional alcohol, with the volume ratio of the solvent mixture to the aqueous solution being at least 3 to 1 and with the suspension developed being agitated until the primarily yielded coarse antibiotic / antibiotics aggregates disintegrate into particles, which have a grain size smaller than 400 µm.
Méthode de production d'antibiotiques / de particules d'antibiotiques caractérisée par le fait qu'une solution aqueuse d'un antibiotique amino glucoside ou une solution aqueuse contenant deux antibiotiques amino glucosides ou plus est mélangée par agitation avec un mélange de solvants contenant de l'isopropanol et au moins un alcool additionnel, le ratio en volume du mélange de solvants et de la solution aqueuse étant d'au moins 3:1, et la suspension créée étant agitée jusqu'à ce que les agrégats grossiers de l'antibiotique / des antibiotiques obtenus à l'origine se désagrègent en particules présentant une granulométrie inférieure à 400 mu m.
Kuehn Klaus-Dieter
Vogt Sebastian
Heraeus Kulzer Gmbh
Macrae & Co.
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