Targeted gene delivery system

Details Targeted gene delivery system Targeted gene delivery system

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2193954

A target-specific gene delivery system is made of enzymatically degradable gelatin and nucleic acids (DNA or RNA) microparticles with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method. Targeting ligands can be attached to the microparticle directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the microparticle surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.

Système de transport d'un gène spécifique d'une cible, composé de microparticules de gélatine dégradable enzymatiquement et d'acides nucléiques (ADN ou ARN) comportant une fraction de liaison ou un ligand de ciblage liés à la surface. Ce système de transport peut être réalisé par un procédé simple. Des ligands de ciblage peuvent être fixés sur une microparticule directement ou par l'intermédiaire d'une fraction de liaison. La structure de la liaison permet de fixer toute molécule sur la surface d'une microparticule, y compris des anticorps, des molécules d'adhérence cellulaire, des hormones et d'autres ligands à spécificité cellulaire.

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