Virulence of streptococci

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 38/16 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2428278

The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention provides a method for modulating virulence of a Streptococcus comprising modifying a genomic fragment of said Streptococcus wherein said genomic fragment comprises at least a functional part of a fragment identifiable by hybridisation in Streptococcus suis to a nucleic acid or fragment thereof as shown in figure 5.

L'invention concerne le domaine du diagnostic et de la vaccination d'infections streptococciques, et la détection de marqueurs de virulence de streptocoques. L'invention concerne un procédé permettant de moduler la virulence d'un Streptococcus consistant à modifier un fragment génomique dudit Streptococcus, ledit fragment génomique comprenant au moins une partie fonctionnelle d'un fragment identifiable par hybridation dans Streptococcus suis à un acide nucléique ou à un fragment dudit acide comme indiqué figure 5.

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