Process for preparing xanthine phosphodiesterase v...

Details Process for preparing xanthine phosphodiesterase v... Process for preparing xanthine phosphodiesterase v...

C - Chemistry, Metallurgy

07

D

C07D 473/06 (2006.01) C07D 233/90 (2006.01)

Patent

CA 2483923

A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound (5) without intermediate purifications or separations, a dihalogenation step to synthesize Compound (7), and a coupling reaction to produce Compound (9).

L'invention concerne un procédé de préparation d'inhibiteurs de la phosphodiéstérase V de la xanthine, ainsi que des composés utilisés dans ledit procédé. Le procédé comprend une méthodologie en cinq étapes pour une synthèse efficace du composé (5) sans purification ou séparation intermédiaire, une étape de dihalogénation pour synthétiser le composé (7) et une réaction de couplage pour produire le composé (9).

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