Synthetic pulmonary surfactant peptides

Details Synthetic pulmonary surfactant peptides Synthetic pulmonary surfactant peptides

C - Chemistry, Metallurgy

07

K

C07K 14/785 (2006.01) A61K 35/42 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2111342

2111342 9222315 PCTABS00018 The present invention contemplates synthetic pulmonary surfactants. In one embodiment, a synthetic pulmonary surfactant of the present invention comprises a pharmaceutically acceptable phospholipid admixed with a polypeptide comprising at least 10 amino acid residues and no more than about 60 amino acid residues, wherein the polypeptide includes a sequence having alternating hydrophobic and hydrophilic amino acid residue regions represented by the formula (ZaUb)cZd. In various alternative embodiments, Z is a hydrophilic amino acid residue independently selected from the group consisting of R and K; U is a hydrophobic amino acid residue independently selected from the group consisting of V, I, L, C, Y and F, with L and C being particularly preferred; a has an average value of about 1 to about 5; b has an average value of about 3 to about 20; c is 1 to 10; and d is 0 to 3, with a value of 0, 1, or 2 being particularly preferred. In another variation, a polypeptide of the present invention, when admixed with a pharmaceutically acceptable phospholipid, forms a synthetic pulmonary surfactant having a surfactant activity greater than the surfactant activity of the phospholipid alone. Methods of synthesizing and using the polypeptides and synthetic surfactants of the present invention are also disclosed.

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