Protein kinase inhibitors and methods for using thereof

Details Protein kinase inhibitors and methods for using thereof Protein kinase inhibitors and methods for using thereof

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/41 (2006.01) A61P 35/00 (2006.01) C07D 209/30 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2664147

The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of TrkA, TrkB, TrkC, Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC , Raf, ROCK-II, Rsk1, and SGK kinases, or a combination thereof.

L'invention concerne des composés et des compositions pharmaceutiques de ceux-ci, qui sont utiles en tant qu'inhibiteurs de la protéine kinase, et des procédés pour utiliser de tels composés pour traiter, améliorer ou empêcher un état associé à une activité kinase anormale ou dérégulée. Dans certains modes de réalisation, l'invention concerne des procédés pour utiliser de tels composés pour traiter, améliorer ou empêcher des maladies ou des troubles qui impliquent une activation anormale de kinases TrkA, TrkB, TrkC, Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, et SGK, ou une combinaison de celles-ci.

Affiliated with

Also associated with

Rating

Protein kinase inhibitors and methods for using thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein kinase inhibitors and methods for using thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein kinase inhibitors and methods for using thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1512834