Methods of determining a chemotherapeutic regimen based on...

Details Methods of determining a chemotherapeutic regimen based on... Methods of determining a chemotherapeutic regimen based on...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2517384

The present invention is directed to a method of predicting a response to a chemotherapeutic regimen based on loss of heterozygosity at the thymidylate synthase locus in cancer tissue. This method comprises determining normal tissue genotype for thymidylate synthase of a patient; determining tumor tissue genotype for thymidylate synthase of said patient; comparing the normal tissue genotype with the tumor tissue genotype; determining whether a loss of heterozygosity at the thymidylate synthase locus has occurred in the tumor tissue based on the comparison of the genotypes; and predicting a response to the chemotherapeutic regimen based on the loss of heterozygosity in the tumor sample.

L'invention porte sur une méthode de prédiction de la réponse à un traitement probatoire de chimiothérapie en fonction en de la baisse d'hétérozygosité au niveau des locus de la thymidylate synthase de tissus cancéreux. Ladite méthode consiste: à déterminer le génotype de la thymidylate synthase d'un tissu normal du patient; à déterminer le génotype de la thymidylate synthase d'un tissu tumoral du patient; à comparer les deux génotypes; à déterminer s'il y a une baisse de l'hétérozygosité détectée au niveau des locus de la thymidylate synthase à l'aide de la comparaison; et à prédire la réponse à un traitement de chimiothérapie en fonction de la perte d'hétérozygosité de l'échantillon tumoral.

Affiliated with

Also associated with

Rating

Methods of determining a chemotherapeutic regimen based on... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of determining a chemotherapeutic regimen based on..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of determining a chemotherapeutic regimen based on... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1513560