A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/55 (2006.01) A61K 9/20 (2006.01) A61K 31/33 (2006.01) A61K 31/395 (2006.01) A61K 31/54 (2006.01) A61K 31/554 (2006.01)
Patent
CA 2659814
The present invention provides stable pharmaceutical compositions comprising a combination of active pharmaceutical ingredients. The pharmaceutical composition of the present invention comprises a moisture sensitive drug, in particular an angiotensin converting enzyme (ACE) inhibitor such as Cilazapril, as an active ingredient, a second pharmaceutically active ingredient such as for example Hydrochlorothiazide, and at least one pharmaceutical excipient, wherein the moisture sensitive active pharmaceutical ingredient is wet granulated with a solution of at least one pharmaceutical excipient, and methods for preparing such stable pharmaceutical compositions.
La présente invention concerne des compositions pharmaceutiques stables comprenant une combinaison d'ingrédients pharmaceutiques actifs. La composition pharmaceutique de la présente invention comprend un médicament sensible à l'humidité, en particulier un inhibiteur de l'enzyme de conversion de l'angiotensine (ACE) tel que le Cilazapril, en tant qu'ingrédient actif, un second ingrédient pharmaceutiquement actif tel que, par exemple, l'hydrochlorothiazide, et au moins un excipient pharmaceutique, l'ingrédient pharmaceutique actif sensible à l'humidité étant granulé par voie humide avec une solution d'au moins un excipient pharmaceutique. L'invention concerne également des procédés de préparation de ces compositions pharmaceutiques stables.
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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