Human alpha 4 receptor subunit of the gaba-a receptor

Details Human alpha 4 receptor subunit of the gaba-a receptor Human alpha 4 receptor subunit of the gaba-a receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2201281

The present invention relates to the cloning of novel cDNA sequences encoding the .alpha.4 and .delta. receptor subunits of the human GABAA receptor; to stably co-transfected eukaryotic cell lines capable of expressing a human GABAA receptor, which receptor comprises at least one of the novel .alpha.4 and .delta. receptor subunits; and to the use of such cell lines in screening for and designing medicaments which act upon the human GAGAA receptor.

L'invention concerne le clonage de nouvelles séquences d'ADN complémentaire codant des sous-unités .alpha.¿4? et .delta. du récepteur GABA-¿A? humain. Elle concerne aussi des lignées cellulaires eucaryotes, co-transfectées de façon stable et pouvant exprimer un récepteur GABA-¿A? humain qui comprend au moins l'une des nouvelles sous-unités .alpha.¿4? ou .delta. de ce récepteur. Elle concerne enfin l'utilisation de telles lignées cellulaires pour trier et concevoir des médicaments qui agissent sur le récepteur GABA-¿A? humain.

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