Ttk peptides and vaccines including the same

Details Ttk peptides and vaccines including the same Ttk peptides and vaccines including the same

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2761393

Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the TTK gene that elicit CTLs are provided. Antigen-presenting cells and isolated CTLs that target such peptides, as well as methods for inducing the antigen-presenting cell, or CTL are also provided. The present invention further provides pharmaceutical compositions containing as active ingredients peptides derived from TTK or polynucleotides encoding the peptides. Furthermore, the present invention provides methods for the treatment and/or prophylaxis (i.e., prevention) of cancers (tumors), and/or the prevention of postoperative recurrence thereof, as well as methods for inducing CTLs, methods for inducing anti-tumor immunity, using the peptides derived from TTK, polynucleotides encoding the peptides, or antigen-presenting cells presenting the peptides, or the pharmaceutical compositions of the present invention.

L'invention porte sur des vaccins peptidiques contre un cancer. En particulier, l'invention porte sur des peptides épitopes issus du gène TTK qui activent les CTL. L'invention porte également sur des cellules présentatrices de l'antigène et sur des CTL isolés qui ciblent de tels peptides, ainsi que sur des procédés pour l'induction de la cellule présentatrice de l'antigène ou du CTL. La présente invention porte en outre sur des compositions pharmaceutiques contenant comme ingrédients actifs des peptides issus de TTK ou des polynucléotides codant pour les peptides. En outre, la présente invention porte sur des procédés pour le traitement et/ou la prophylaxie (c'est-à-dire la prévention) de cancers (tumeurs), et/ou la prévention de la rechute postopératoire de ceux-ci, ainsi que sur des procédés pour l'induction de CTL, des procédés pour l'induction d'une immunité antitumorale, utilisant les peptides issus de TTK, des polynucléotides codant pour les peptides ou des cellules présentatrices de l'antigène présentant les peptides, ou les compositions pharmaceutiques de la présente invention.

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