Use of thiadiazolo[4,3-a]pyridine derivatives

Details Use of thiadiazolo[4,3-a]pyridine derivatives Use of thiadiazolo[4,3-a]pyridine derivatives

A - Human Necessities

61

K

A61K 31/435 (2006.01) A61K 31/437 (2006.01)

Patent

CA 2318237

Use of compounds of the formula (I), in which X and X, identically or differently, are hydrogen, a C - to C -alkyl radical or a halogen atom or, if they are in adjacent positions, form a fused phenyl ring together with the carbon atoms carrying them, and R is an optionally substituted carbocyclic or heterocyclic saturated or unsaturated radical, and their physiologically tolerable salts, for the production of medicaments for diseases which are modulated via inhibition of phosphodiesterase(s) by cyclic nucleotides, in particular cyclic adenosine monophosphate. The diseases are more particularly proliferative disorders, including tumors, lymphomas, leukaemias, atherosclerosis and glomerulopathies, memory and/or learning ability disorders (inter alia Alzheimer's), impotence, erectile insufficiency and obesity, ischaemic or thrombolytic disorders, such as coronary infarct or cerebral infarct and additionally serum disorders.

Cette invention, qui a trait à l'emploi de composés correspondant à la formule (I) dans laquelle X?1¿ et X?2¿, de manière identique ou différente, représentent un hydrogène, un radical alkyle portant de 1 à 6 atomes de carbone ou un atome d'halogène ou bien, s'ils se trouvent sur des positions adjacentes, forment un phényle à anneaux condensés avec les atomes de carbone les portant et dans laquelle R représente un radical carbocyclique ou hétérocyclique, saturé ou insaturé, éventuellement substitué, concerne également les sels physiologiquement admissibles de ces composés et ce, aux fins de la préparation de médicaments destinés à traiter des affections modulées, via l'inhibition d'une phosphodiestérase ou de phosphodiestérases, par des nucléotides cycliques, notamment l'adénosine-monophosphate cyclique.

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