Ternary non-lamellar lipid compositions

Details Ternary non-lamellar lipid compositions Ternary non-lamellar lipid compositions

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 38/11 (2006.01)

Patent

CA 2554052

The present invention provides a particulate composition including; a) at least 50 % of at least one structure forming amphiphile, b) 0 to 40 % of at least one structure swelling amphiphile, and c) 2 to 20 % of at least one dispersion stabilising polymeric amphiphile, where all parts are by weight relative to the sum of the weights of a+b+c and wherein the composition comprises non-lamellar particles or forms non-lamellar particles when contacted with an aqueous fluid. Where component b) is 0 % then component a) comprises at least two structure forming amphiphiles. The invention also provides pharmaceutical compositions of the compositions and kits containing the compositions for establishing a pharmaceutical formulation of an active agent.

La présente invention se rapporte à une composition particulaire comportant: a) au moins 50 % d'au moins un composant amphiphile permettant la formation d'une structure, b) 0 à 40 % d'au moins un composé amphiphile permettant de gonfler une structure et c) 2 à 20 % d'au moins un composé amphiphile polymère permettant de stabiliser une dispersion, toutes les fractions étant indiquées par poids par rapport à la somme des poids de a + b + c, et ladite composition comprenant des particules non lamellaires et formant des particules non lamellaires lors d'une mise en contact avec un fluide aqueux. Lorsque le composant b) est 0 % alors le composant a) comprend au moins deux composés amphiphiles pouvant former une structure. L'invention se rapporte également à des compostions pharmaceutiques contenant les compositions ci-dessus ainsi qu'à des trousses contenant ces compositions et permettant l'établissement d'une formulation pharmaceutique d'un agent actif.

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