A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 35/76 (2006.01) A61P 35/00 (2006.01) C07K 14/075 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2487811
The invention relates to the use of a virus, preferably an adenovirus, for the production of a medicament or for replication in cells. Said virus is replication-deficient in cells which do not contain YB-1 in the core while coding for an oncogene or oncogene product, especially an oncogene protein, which transactivates at least one viral gene, preferably an adenoviral gene, said gene being selected among the group comprising E1B55kDa, E4orf6, E4orf3, and E3ADP. The oncogene protein represents the viral oncogene protein E1A which is mutated, for example. Said medicament is used particularly for treating tumors showing multiple resistance against cytostatic drugs.
L'invention concerne l'utilisation d'un virus, de préférence d'un adénovirus, pour la production d'un médicament, ledit virus étant un virus à réplication déficiente dans les cellules qui ne présentent YB-1 dans le noyau. Ledit virus code pour un oncogène ou un produit d'oncogène, notamment une protéine oncogénique, qui transactive au moins un gène de virus, de préférence un gène d'adénovirus, ledit gène étant sélectionné dans le groupe qui comprend E1B55kDa, E4orf6, E4orf3 et E3ADP.
Borden Ladner Gervais Llp
Holm Per Sonne
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