Ready-to-use paracetamol injection solutions containing...

Details Ready-to-use paracetamol injection solutions containing... Ready-to-use paracetamol injection solutions containing...

A - Human Necessities

61

K

A61K 47/10 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2463681

The present invention refers to ready-to-use highly stable paracetamol injectable solutions, prepared by mixing paracetamol, wter, propylene glycol, and a citrate buffer. (pH 4.5 to 6.5), and by heating said solution under preset conditions. The resulting solution may be stored for an extended period of time within a wide range of temperatures, with no paracetamol precipitation and/or its chemical modification.

La présente invention concerne des solutions injectables à base de paracétamol, hautement stables et prêtes à l'emploi, que l'on prépare en mélangeant du paracétamol, de l'eau, du propylène glycol et un tampon de citrate (pH de 4,5 à 6,5), puis en chauffant ladite solution dans des conditions prédéterminées. La solution obtenue peut être conservée pendant une longue période de temps à une large gamme de températures, sans que le paracétamol ne subisse précipitation ni modification chimique.

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