Substituted lactams as inhibitors of a.beta. protein production

Details Substituted lactams as inhibitors of a.beta. protein production Substituted lactams as inhibitors of a.beta. protein production

C - Chemistry, Metallurgy

07

D

C07D 243/24 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61K 38/00 (2006.01) A61P 25/28 (2006.01) C07D 223/12 (2006.01) C07D 223/18 (2006.01) C07D 243/12 (2006.01) C07D 401/04 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2404273

This invention relates to novel lactams of Formula (I) having drug and bio- affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.

L'invention concerne de nouveaux lactames de formule (I) présentant des propriétés médicamenteuses et ayant une influence biologique, leurs compositions pharmaceutiques et leurs méthodes d'utilisation. Ces nouveaux composés inhibent le traitement de la protéine précurseur amyloïde et, plus spécifiquement, la production de peptide A.beta., agissant ainsi pour prévenir la formation de dépôts neurologiques de protéine amyloïde. Plus particulièrement, la présente invention concerne le traitement de troubles neurologiques liés à la production de .beta.-amyloïde, tels que la maladie d'Alhzeimer et le syndrome de Down.

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