Forms a and b of...

C - Chemistry – Metallurgy – 07 – D

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C07D 277/48 (2006.01)

Patent

CA 2180378

Image Ebrotidine is indicated for the treatment of duodenal ulceration, benign gastric or pre-pyloric peptic ulcer, and nonsteroidal anti-inflammatory drug-induced gastroduodenal lesions. Ebrotidine in combination with antibiotics is used for the eradication of Helicobacter pylori in duodenal ulcer patients.

On a identifié deux formes de N-[[[2-[[[2-[(diaminométhylène)amino]-4-thiazolyl]méthyl]thio]éthyl]amino]méthylène]-4-bromobenzénosulfonamide. L'invention décrit également un procédé d'obtention de ces deux formes ainsi que leur utilisation.

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