Optimized messenger rna

Details Optimized messenger rna Optimized messenger rna

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/745 (2006.01) C12N 9/40 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2425732

The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons.

L'invention concerne une séquence synthétique d'acides nucléiques, codant pour une protéine, dans laquelle on remplace au moins un codon non commun ou un codon moins commun par un codon commun. Cette séquence peut comprendre un allongement continu d'au moins 90 codons qui sont tous des codons communs.

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