Compositions comprising blockers of l-dopa renal cell...

Details Compositions comprising blockers of l-dopa renal cell... Compositions comprising blockers of l-dopa renal cell...

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 31/35 (2006.01)

Patent

CA 2402712

A pharmaceutical composition for the treatment of Parkinson's disease comprises L-DOPA and at least one compound capable of blocking the L-DOPA renal cell outward transfer pathway; said blocking compound being chosen from (a) a flavonoid phenyl benzopyran derivative); (b) a trans-stilbene derivative; or (c) phloretin [3-(4- hydroxyphenyl)-1-(2, 4, 6-trihydroxyphenyl)-1-propanone]. The composition may also comprise an inhibitor of the enzyme amino acid decarboxylase (AADC), such as carbidopa or benserazide, and/or an inhibitor of the enzyme catechol-O-methyl transferase (COMT), such as entacapone or tolcapone. The composition is preferably administered in solid form and the L- DOPA may be administered simultaneously or sequentially with the L-DOPA renal cell outward transfer blocking compound.

L'invention concerne une composition pharmaceutique destinée au traitement de la maladie de Parkinson comprenant du <u>L</u>- DOPA et au moins un composé permettant de bloquer le processus de transfert vers l'extérieur de la cellule rénale, ce composé de blocage étant choisi parmi (a) un dérivé de benzopyranne phényle flavonoïde, (b) un dérivé de trans-stilbène ou (c) une phlorétine [3-(4-hydroxyphényl)-1-(2, 4,6-trihydroxyphényl)-1-propanone]. Cette composition peut éventuellement comprendre un inhibiteur de décarboxylase d'acide aminé enzymatique (AADC), tel qu'un carbidopa ou un bensérazide, et/ou un inhibiteur d'enzyme de catéchol-O-méthyle transférase (COMT), tel qu'un entacapone ou un tolcapone. La composition est, de préférence, administrée sous forme solide et le <u>L</u>-DOPA peut être administré simultanément ou séquentiellement avec le composé de blocage du transfert vers l'extérieur de la cellule rénale <u>L</u>-DOPA.

Affiliated with

Also associated with

Rating

Compositions comprising blockers of l-dopa renal cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions comprising blockers of l-dopa renal cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions comprising blockers of l-dopa renal cell... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1517198