A novel smad3 splice variant as a target in chronic renal...

Details A novel smad3 splice variant as a target in chronic renal... A novel smad3 splice variant as a target in chronic renal...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2238670

sMAD3d polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing sMAD3d polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, atherosclerosis, and fibrosis, among others, and diagnostic assays for such conditions.

Divulgation de polypeptides et de polynucléotides sMAD3d, ainsi que de méthodes de production de tels polypeptides par des techniques de recombinaison. Des méthodes pour utiliser les polypeptides et les polynucléotides sMAD3d dans la conception de protocoles pour le traitement de l'insuffisance rénale chronique, de l'athérosclérose et de la fibrose, entre autres, de même que des épreuves diagnostiques pour ces conditions sont également dévoilées.

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