Animals with targeted gene disruption

Details Animals with targeted gene disruption Animals with targeted gene disruption

C - Chemistry, Metallurgy

12

N

C12N 15/27 (2006.01) A01K 67/027 (2006.01) A61K 9/12 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) C12N 15/19 (2006.01)

Patent

CA 2184707

The invention provides transgenic non-human animals in which genes encoding colony-stimulating factors have been specifically disrupted, so that the animals do not express the respective factors. In specific embodiments the invention provides mice in which expression of GM-CSF, G-CSF and/or CSF-1 is disrupted. These animals do not produce any bioactive CSF of the respective type. They are useful as models for a variety of conditions, and particularly for testing of therapeutic methods.

Animaux non humains transgéniques dans lesquels des gènes codant des facteurs de stimulation de colonies (CSF) ont été spécifiquement rompus, si bien que lesdits animaux n'expriment pas les facteurs respectifs. Dans des modes de réalisation spécifiques, la présente invention concerne des souris dans lesquelles l'expression de CSF de granulocytes macrophages (GM-CSF), de CSF de granulocytes (G-CSF) et/ou de CSF-1 est perturbée. Ces animaux ne produisent pas de CSF bioactifs du type respectif. Ils sont utiles en tant que modèles pour toute une série d'états pathologiques, et particulièrement pour le test de méthodes thérapeutiques.

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