Targeting of innate immune response to tumor site

Details Targeting of innate immune response to tumor site Targeting of innate immune response to tumor site

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2713137

The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environ-ment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.

La présente invention concerne des microparticules ou des nanoparticules pour le traitement de tumeurs, lequel traitement comprend : (i) un agent qui cible la tumeur ou l'environnement de la tumeur; et (ii) au moins un inducteur qui stimule une réponse immune souhaitée dans l'environnement de la tumeur, conduisant à une apoptose tumorale. Les composants (i) et (ii) sont liés de manière non covalente ou de manière covalente à la surface desdites microparticules ou nanoparticules. L'agent de ciblage est un agent qui reconnaît un antigène et se lie à celui-ci, un récepteur ou d'autres molécules découvertes sur la surface de cellules tumorales ou dans l'environnement de la tumeur et sont de préférence des anticorps.

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