Somatostatin analogs for the treatment of cancer

Details Somatostatin analogs for the treatment of cancer Somatostatin analogs for the treatment of cancer

C - Chemistry, Metallurgy

07

K

C07K 14/655 (2006.01) A61K 38/31 (2006.01) A61P 35/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2385910

The present invention encompasses novel peptides that are agonists to somatostatin and the use of the agonists for treatment of cancer. The invention particularly relates to the design and synthesis of novel analogs of somatostatin incorporating .alpha., .alpha.-dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.

L'invention concerne des nouveaux peptides qui sont des agonistes de la somatostatine, ainsi que l'utilisation de ceux-ci de le traitement du cancer. L'invention concerne en particulier la conception et la synthèse des nouveaux analogues de la somatostatine renfermant des acides aminés .alpha., .alpha.-dialkylés selon un mode spécifique à un site. L'invention concerne également des procédés de préparation de ces peptides, des compositions renfermant ces peptides et des applications pharmacologiques de ces peptides, notamment dans le traitement et la prévention du cancer.

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