Methods of modulating epithelial-mesenchymal transition and...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) C12N 5/071 (2010.01) C12N 5/077 (2010.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 35/12 (2006.01) A61P 17/02 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/113 (2010.01)

Patent

CA 2653288

The present invention relates generally to the fields of treatment, prophylaxis and diagnosis of cell-based and fibrotic conditions in animals including mammals. More particularly, the present invention contemplates the use of agents which modulate epithelial-mesenchymal transition (EMT) processes and mesenchymal-epithelial transition (MET) processes and hence are useful in the treatment of a range of conditions including inhibiting metastasis of solid tumors and the development of fibrosis, treating metastatic disease and in promoting wound healing. Diagnostic protocols to assess EMT and MET or its stage of development also form part of the present invention. The EMT and MET modulating agents are also useful in regulating gene expression and, hence, represent useful therapeutic and research tools.

La présente invention concerne d'une manière générale les domaines du traitement, de la prophylaxie et du diagnostic de pathologies fibrotiques associées aux processus cellulaires chez les animaux, y compris les mammifères. Plus particulièrement, la présente invention concerne l'utilisation d'agents qui modulent les processus de transition épithéliale-mésenchymateuse (TEM) de même que les processus de transition mésenchymateuse-épithéliale (TME) et qui, par conséquent, se révèlent utiles dans le traitement d'une variété de pathologies incluant l'inhibition de métastases de tumeurs solides et du développement d'une fibrose, le traitement d'une maladie métastatique ainsi que l'amélioration de la cicatrisation de plaies. Des protocoles de diagnostic destinés à l'évaluation de la TEM et de la TME, ou de leur état de développement, font également partie du domaine de la présente invention. Les agents de modulation de la TEM et de la TME se révèlent également utiles pour la régulation de l'expression génique et, par conséquent, ils représentent une thérapeutique et des outils de recherche utiles.

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