Substituted indazole derivatives and their use as...

Details Substituted indazole derivatives and their use as... Substituted indazole derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/675 (2006.01) C07D 401/00 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 487/04 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2258285

The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R, R1 and R2 are as defined herein. The invention further relates to pharmaceutical compositions containing, and methods of using, the compounds of formula (I), or acceptable salts thereof, for the inhibition of phosphodiesterase (PDE) type IV or the production of tumor necrosis factor (TNF) in a mammal.

L'invention concerne des composés de la formule (I) ainsi que leurs sels pharmaceutiquement acceptables, formule dans laquelle R, R¿1? et R¿2? ont la notation définie dans la description. L'invention concerne également des compositions pharmaceutiques contenant les composés de la formule (I), ou leurs sels acceptables, et des procédés d'utilisation desdits composés, pour l'inhibition de la phosphodiestérase (PDE) type IV ou la production du facteur de nécrose tumorale (TNF) chez un mammifère.

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