Motif-grafted hybrid polypeptides and uses thereof

Details Motif-grafted hybrid polypeptides and uses thereof Motif-grafted hybrid polypeptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 16/10 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2481437

Provided herein are hybrid polypeptides that specifically bind to a disease- associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious from of a prion (PrPSc) is provided.

L'invention concerne des polypeptides hybrides qui se lient spécifiquement à un isoforme associé à une maladie d'un polypeptide impliqué dans des maladies d'agrégation de protéines. Ces polypeptides hybrides peuvent être utilisés pour le diagnostique et le traitement de telles maladies. Dans un mode de réalisation particulier, l'invention concerne une protéine hybride qui se lie spécifiquement à la forme infectieuse d'un prion (PrP?Sc¿).

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