Convenient process for the preparation of chiral or racemic...

Details Convenient process for the preparation of chiral or racemic... Convenient process for the preparation of chiral or racemic...

C - Chemistry, Metallurgy

07

C

C07C 215/28 (2006.01) C07C 213/08 (2006.01)

Patent

CA 2130296

This invention pertains to an improved process for preparing chiral or racemic phenylalaninol (PAO) by hydrogenation of L(+)- or racemic 2-amino-1-phenyl-1,3- propanediol (APPD) in the presence of a strong volatile acid. Furthermore, a more valuable form of PAO such like N-blocked PAO was found to be directly produceable from the hydrogenation mixture without isolation of PAO, when a volatile acid was used as the medium of the hydrogenation reaction.

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