Ex vivo and in vivo expression of the thrombomodulin gene...

Details Ex vivo and in vivo expression of the thrombomodulin gene... Ex vivo and in vivo expression of the thrombomodulin gene...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2674563

The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel in vivo using a gutless adenovirus vector. Another. aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM.protein or its variant using a stent.

L'invention concerne des procédés et des compositions destinés au traitement de maladies cardiovasculaires et vasculaires périphériques faisant appel à des technologies d'administration génique ex vivo et in vivo. Dans un aspect, l'invention concerne un procédé permettant de traiter une maladie vasculaire par introduction d'une séquence ADN codant une protéine TM ou son variant dans un segment d'un vaisseau sanguin in vivo au moyen d'un vecteur adénoviral n'exprimant plus de gènes viraux. Dans un autre aspect, l'invention concerne un procédé permettant d'administrer un vecteur adénoviral n'exprimant plus de gènes viraux transportant une séquence ADN codant une protéine TM ou son variant au moyen d'une endoprothèse.

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