Pharmaceutical depot comprising n-{5- t (cyclopropylamino)...

Details Pharmaceutical depot comprising n-{5- t (cyclopropylamino)... Pharmaceutical depot comprising n-{5- t (cyclopropylamino)...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 31/165 (2006.01)

Patent

CA 2725822

A pharmaceutical depot comprising (i) N-{5-[(cyclopropylamino)carbonyl]-2- methylphenyl}-3-fluoro-4- (pyridin-2-ylmethoxy)benzamide, or a pharmaceutically-acceptable salt thereof, as a pharmaceutical agent (PA) and (ii) a polymer which degrades to create an acidic microclimate, wherein the PA is released from the polymer upon polymer degradation.

L'invention porte sur un produit pharmaceutique retard comprenant (i) du N-{5-[(cyclopropylamino)carbonyl]-2-méthylphényl}-3-fluoro-4-(pyridin-2-ylméthoxy)benzamide, ou un sel pharmaceutiquement acceptable de celui-ci, en tant qu'agent pharmaceutique (PA), et (ii) un polymère qui se dégrade pour créer un microclimat acide, le PA étant libéré à partir du polymère lors de la dégradation du polymère.

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